• Neuroscience letters · Jun 2004

    Qualitative sex differences in kappa-opioid analgesia in mice are dependent on age.

    • Wendy F Sternberg, Jennifer Ritchie, and Jeffrey S Mogil.
    • Department of Psychology, Haverford College, 370 Lancaster Avenue, Haverford, PA 19041, USA. wsternbe@haverford.edu
    • Neurosci. Lett. 2004 Jun 10;363(2):178-81.

    AbstractThe effects of aging on sex differences in analgesia from the kappa-opioid agonist, U50,488H (U50), were examined in C57BL/6J mice. U50 analgesia can be blocked by the N-methyl-d-aspartate receptor antagonist, MK-801 (MK), in male rodents and gonadectomized females, but not hormonally intact or estrogen-replaced females, suggesting the existence of alternate neurochemical mediation in females. We now report that MK antagonism of U50 analgesia is age-dependent in females. That is, reproductively senescent females display MK-sensitive U50 analgesia qualitatively similar to that displayed by males or hormonally deprived young females. Age-related reductions in U50 analgesic magnitude were also observed in females. Thus, age and gender are likely to alter the clinical efficacy of analgesic drugs active at kappa-opioid receptors.

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