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Randomized Controlled Trial Comparative Study Clinical Trial
Pretreatment with alfentanil reduces pain caused by propofol.
- J E Fletcher, C R Seavell, and D J Bowen.
- Department of Anaesthetics, Royal Hampshire County Hospital, Winchester.
- Br J Anaesth. 1994 Mar 1;72(3):342-4.
AbstractWe have compared two groups (n = 22) of unpremedicated patients to determine if the pain caused by injection of propofol could be modified by alfentanil. In group I, alfentanil 1 mg was given as a bolus i.v. injection 15 s before administration of propofol i.v., while group II received saline. Propofol was given in 20-mg increments every 4 s. All injections were given through the same i.v. cannula on the dorsum of one hand. We found that alfentanil pretreatment reduced pain on injection of propofol (P = 0.001).
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