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J Spinal Disord Tech · Nov 2016
Novel Hemi-Staple for the Fusionless Correction of Pediatric Scoliosis: Influence on Intervertebral Disks and Growth Plates in a Porcine Model.
- Mark Driscoll, Carl-Éric Aubin, Alain Moreau, Yaroslav Wakula, Samira Amini, and Stefan Parent.
- *École Polytechnique de Montréal, Biomedical Engineering Institute †Research Center ‡Laboratory in Molecular Genetics of Musculoskeletal Diseases, Sainte-Justine University Hospital Center Departments of §Stomatology, Faculty of Dentistry ∥Biochemistry, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.
- J Spinal Disord Tech. 2016 Nov 1; 29 (9): 457-464.
Study DesignIn vivo porcine model utilized to evaluate the influence of an intravertebral fusionless growth modulating device (hemi-staple) on intervertebral disks and growth plates.ObjectiveTo evaluate the radiographic and histologic changes in disks and growth plates with the purpose of measuring influence of the explored hemi-staple.Summary Of Background DataFusionless growth modulation for the early treatment of scoliosis should insure the long-term viability of the intervertebral disk and successfully reduce or arrest local growth. A novel hemi-staple that proved effective in the control of coronal spinal alignment warranted further analyses of its influence on the disk health and growth-plate morphology.MethodsA hemi-staple that inhibited local vertebral growth exclusive of the disk was introduced over T5-T8 in 4 immature pigs (16 vertebrae; experimental), whereas 3 underwent surgery without instrumentation (sham) and 2 had no intervention (control). Three-month follow-up before animal euthanasia provided radiographic (disk height and health) and histologic (growth plate morphology, disk health, and type X collagen distribution) analyses.ResultsNo postoperative complications were experienced. Radiographic data returned inverse disk wedging (greater disk height adjacent to device, 2.6±0.7 mm compared with the noninstrumented side, 1.8±0.5 mm) in experimental segments and suggested disk viability. Histologic data confirmed device growth modulation through significant local reduction of growth plate hypertrophic zone (125.64±16.61 μm and 61.16±8.25 μm in noninstrumented and instrumented sections, respectively) and cell height (16.14±1.87 μm and 9.22±1.57 μm in noninstrumented and instrumented sections, respectively). A variability of disk health, dependant of device insertion location, was observed. Type X collagen was consistently identified in experimental growth plates and absent from intervertebral disks.ConclusionsHemi-staples decreased growth plate hypertrophic zone and cell height, and, depending on device insertion site, showed positive signs of disk health sustainability. Spinal growth modulation achieved exclusive of disk compression, as practiced by this method, offers unique advantages over other fusionless techniques. This technique may provide a suitable and attractive alternative for the early treatment of idiopathic scoliosis.
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