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Artif Cells Blood Substit Immobil Biotechnol · Aug 2011
Dose response of sodium nitrite on vasoactivity associated with HBOC-201 in a swine model of controlled hemorrhage.
- Françoise Arnaud, Anke H Scultetus, Bobby Kim, Ashraful Haque, Biswajit Saha, Savita Nigam, Paula Moon-Massat, Charles Auker, Richard McCarron, and Daniel Freilich.
- Naval Medical Research Center, Operational and Undersea Medicine, NeuroTrauma Department, Silver Spring, MD 20910-7500, USA. Francoise.arnaud@med.navy.mil
- Artif Cells Blood Substit Immobil Biotechnol. 2011 Aug 1;39(4):195-205.
AbstractSodium nitrite (NaNO(2)) was evaluated in a 55% EBV hemorrhage swine model to mitigate the increased blood pressure due to HBOC-201. Animals were resuscitated by three 10 ml/kg infusions of either HBOC-201 or Hextend with and without NaNO(2). All vital signs, coagulation and blood chemistry were measured for 2 hr. HBOC-201-vasoconstriction was attenuated only after the first 10.8 μmol/kg NaNO(2) infusion. Complete abolition was obtained with the highest 3 NaNO(2) dose, but side effects were observed. There was no reduction in platelet function due to NaNO(2). NaNO(2) ability to reduce HBOC-201 vasoactivity was transient and 10.8 μmol/kg NaNO(2) seems an acceptable dose for further investigation.
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