• Judith L Hough, Trang M T Pham, and Andreas Schibler.
• 1Paediatric Critical Care Research Group, Paediatric Intensive Care Unit, Mater Children's Hospital, South Brisbane, QLD, Australia. 2School of Physiotherapy, Australian Catholic University, Banyo, QLD, Australia. 3Critical Care of the Newborn Program, Mater Research, South Brisbane, QLD, Australia.
• Pediatr Crit Care Me. 2014 Jun 1;15(5):e214-9.

ObjectiveTo assess the effect of delivering high-flow nasal cannula flow on end-expiratory lung volume, continuous distending pressure, and regional ventilation distribution in infants less than 12 months old with bronchiolitis.DesignProspective observational clinical study.SettingNineteen bed medical and surgical PICU.PatientsThirteen infants with bronchiolitis on high-flow nasal therapy.InterventionsThe study infants were measured on a flow rate applied at 2 and 8 L/min through the high-flow nasal cannula system.Measurements And ResultsVentilation distribution was measured with regional electrical impedance amplitudes and end-expiratory lung volume using electrical impedance tomography. Changes in continuous distending pressure were measured from the esophagus via the nasogastric tube. Physiological variables were also recorded. High-flow nasal cannula delivered at 8 L/min resulted in significant increases in global and anterior end-expiratory lung volume (p < 0.01) and improvements in the physiological variables of respiratory rate, SpO2, and FIO2 when compared with flows of 2 L/min.ConclusionIn infants with bronchiolitis, high-flow nasal cannula oxygen/air delivered at 8 L/min resulted in increases in end-expiratory lung volume and improved respiratory rate, FIO2, and SpO2.

30 keywords...

hide…