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Clinical rheumatology · Jan 1998
Comparative StudyKnee and/or hip joint destruction in rheumatoid arthritis is associated with HLA-DRB1*0405 in Japanese patients.
- S Wakitani, K Kuwata, K Imoto, N Murata, H Oonishi, and T Ochi.
- Department of Orthopaedic Surgery, Osaka-Minami National Hospital, Kawachinagano, Japan.
- Clin. Rheumatol. 1998 Jan 1;17(6):485-8.
AbstractTo determine the prognostic factors for knee and/or hip joint destruction in rheumatoid arthritis (RA) patients, we typed 379 RA patients for HLA-DRB alleles and analysed the antigen frequencies. The DRB1*0405 antigen frequency in RA patients who underwent total knee replacement and/or total hip replacement was significantly higher than in those who did not have replacements, which meant that DRB1*0405 was associated with knee and/or hip joint destruction. This finding may be of value for predicting knee and/or hip joint destruction in RA.
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