• C Duchene, S Olindo, N Chausson, S Jeannin, P Cohen-Tenoudji, and D Smadja.
• Service de Neurologie, CHU Pierre-Zobda-Quitman, La Meynard, 97200 Fort-de-France, Martinique, France.
• Rev Neurol France. 2010 Apr 1;166(4):438-42.

IntroductionCannabis is the most consumed drug in the world particularly in young adults. Few reports have suggested a causal role of cannabis in the development of cerebral or cardiovascular events. We describe the first association of myocardial infarction and stroke after heavy cannabis consumption in a 45-year-old woman.ObservationStroke occurred in relation with a right carotid and middle cerebral artery thrombosis after cannabis abuse. The patient was successfully treated with intravenous rt-PA. Two days after her admission, she presented a myocardial infarction due to a coronary thrombosis. Cerebral and coronary arteries were angiographically normal. Etiological tests were negative and a toxic cause in relation with cannabis consumption was concluded.ConclusionCannabis can be associated with vascular events by different mechanisms. Thrombosis may occur in cerebral and/or coronary arteries. We suggest that it might be useful to search for cannabis consumption systematically in young subjects victims of stroke and myocardial infarction.2009 Elsevier Masson SAS. All rights reserved.

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