• Eur. J. Clin. Microbiol. Infect. Dis. · Sep 2007

    Soluble triggering receptor expressed on myeloid cells-1 for distinguishing bacterial from aseptic meningitis in adults.

    • J Bishara, N Hadari, M Shalita-Chesner, Z Samra, O Ofir, M Paul, N Peled, S Pitlik, and Y Molad.
    • Infectious Diseases Unit, Rabin Medical Center, Beilinson Hospital, Petah Tiqwa, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. bishara@netvision.net.il
    • Eur. J. Clin. Microbiol. Infect. Dis. 2007 Sep 1;26(9):647-50.

    AbstractThe aim of the present study was to evaluate whether soluble triggering receptor expressed on myeloid cells (sTREM-1) is present in the cerebrospinal fluid (CSF) of patients with acute meningitis and if its presence can predict bacterial infection. We found elevated levels of sTREM-1 in the CSF of seven of the nine (78%) patients with culture-positive specimens and in none of 12 (0%) patients with culture-negative specimens (sensitivity: 78%; specificity: 100%). The area under the receiver operating characteristic curve for sTREM-1 in the CSF as a predictor for bacterial meningitis was 0.889. This suggests that sTREM-1 is upregulated in the CSF of patients with bacterial meningitis with high specificity and that its presence can potentially assist clinicians in the diagnosis of bacterial meningitis.

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