• Margit Thyr, Anneli Sundholm, Lawrence Teeland, and Vivi-Anne Rahm.
• Department of Children's Health, Bollnäs Health Centre, Bollnäs, Sweden. margit.thyr@lg.se
• Acta Paediatr. 2007 Feb 1;96(2):233-6.

AimTo evaluate oral glucose as an analgesic to reduce infant distress after immunization during the first year of life and to investigate if these effects change during this period.MethodsA prospective controlled trial of the effectiveness of glucose on crying response to immunizations at 3, 5 and 12 months of age. A total of 110 infants were randomized to receive 2 mL of 30% glucose or water. The same solution was given at 3, 5 and 12 months. Crying was registered from onset of the injection up to 120 seconds. Infanrix Polio Hib was administered intra-muscular in the thigh. Observation nurse and parents were blind to the nature of the solution.ResultsAdministration of glucose reduced the mean crying time by 22% at 3 months, 62% at 5 months and 52% at 12 months. The difference was significant at 5 and at 12 months. In the water group, there was a significant correlation between the children who cried at 3 months and who subsequently cried at 5 and 12 months. No correlations were found in the glucose group.ConclusionSweet solution can be used as a simple and safe method to reduce the distress following immunization in infants up to 12 months.

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