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Rev Esp Anestesiol Reanim · Feb 2013
Case Reports[Effect of sub-anaesthetic doses of ketamine in the postoperative period in a patient with uncontrolled depression].
- M Cortiñas-Saenz, M B Alonso-Menoyo, C L Errando-Oyonarte, I Alférez-García, and M A Carricondo-Martínez.
- Servicio de Anestesiología y Reanimación, Hospital Torrecárdenas, Almería, España. stl967523977@wanadoo.es
- Rev Esp Anestesiol Reanim. 2013 Feb 1;60(2):110-3.
AbstractRecent studies indicate that the intravenous infusion of ketamine hydrochloride (an N-methyl-D-aspartate receptor antagonist) leads to a rapid reduction in depressive symptoms. A 42 year-old woman with breast cancer and major depression resistant to medical treatment received a 90 minute intravenous infusion of 0.3 mg/kg ketamine for 5 consecutive days. A significant reduction from 22 to 13 (-41%) was observed in the symptoms assessed using the Hamilton scale, with the effect maintained for 14 days. The possible therapeutic mechanism is discussed.Copyright © 2011 Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor. Published by Elsevier España, S.L. All rights reserved.
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