• J D Herrington, P Kwan, R R Young, E Lagow, L Lagrone, and M W Riggs.
• Department of Pharmacy, Scott & White Memorial Hospital, Temple, TX 76508, USA.
• Pharmacotherapy. 2000 Nov 1;20(11):1318-23.

Study ObjectivesTo compare the antiemetic effectiveness and safety of oral granisetron plus dexamethasone with those of oral ondansetron plus dexamethasone administered before emetogenic chemotherapy.DesignRandomized, prospective, multicenter, open-label study.SettingsUniversity-teaching hospital and veterans health care system.PatientsSixty-one chemotherapy-naïve patients scheduled to receive emetogenic antineoplastic agents.InterventionA single-dose oral granisetron 1 mg and dexamethasone 12 mg or single-dose oral ondansetron 16 mg and dexamethasone 12 mg was administered before chemotherapy.Measurements And ResultsTwenty-four hours after administration patients were contacted to assess nausea, emesis, and adverse events. There were no statistical differences in frequency of nausea or emesis between groups. Seventy-six percent and 82% of patients receiving ondansetron and granisetron, respectively, experienced no emesis 24 hours after chemotherapy. Complete protection from nausea occurred in 58% and 46% of patients receiving the drugs, respectively. Adverse events were similar between groups.ConclusionOral granisetron 1 mg and ondansetron 16 mg plus dexamethasone are safe and effective in preventing nausea and vomiting related to emetogenic chemotherapy.

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