• Expert Opin Drug Saf · Nov 2005

    Review

    The safety and efficacy of the use of vasopressin in sepsis and septic shock.

    • Stephen J Wilson, Saurabh S Mehta, and Mark C Bellamy.
    • Intensive Care Unit, St James's University Hospital, Leeds, LS9 7TF, UK.
    • Expert Opin Drug Saf. 2005 Nov 1;4(6):1027-39.

    AbstractSepsis remains a significant problem and cause of morbidity and mortality in intensive care. Vasopressin infusions are currently used as rescue therapy for the treatment of vasodilatory, catecholamine-resistant septic shock. At present, there are no large randomised, controlled trials in the literature investigating vasopressin in this role, although two such studies are currently ongoing in Canada. This review outlines the pathophysiology of sepsis and that of vasopressin in sepsis and reviews the available evidence for the use of vasopressin in sepsis and septic shock. A review of the safety data for vasopressin in this indication is included. Recommendations for the use of vasopressin in septic shock, along with suggestions for the direction of further work in the field are presented.

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