• Blood purification · Jan 2012

    Haemodynamic Impact of a slower pump speed at start of continuous renal replacement therapy in critically Ill adults with acute kidney injury: a prospective before-and-after study.

    • Glenn M Eastwood, Leah Peck, Helen Young, Michael Bailey, Michael C Reade, Ian Baldwin, and Rinaldo Bellomo.
    • Austin Hospital, Heidelberg, Vic., Australia. glenn.eastwood@austin.org.au
    • Blood Purif. 2012 Jan 1;33(1-3):52-8.

    Background And ObjectivePatients are at risk of haemodynamic instability when starting continuous renal replacement therapy (CRRT).MethodsWe compared data for 'routine-protocol' pump speed increases of 50 ml/min over 1-4 min with 'slower' increases of 20-50 ml/min over 3-10 min to achieve an operating blood flow of 200 ml/min.ResultsWe studied 21 routine and 20 slower CRRT starts. 'Routine protocol' starts reached the target pump speed more quickly than the slower CRRT start (p < 0.05). Heart rate was higher in the routine group compared to the slower group at baseline (p < 0.01) and remained so throughout. There were no significant changes in central venous pressure or mean arterial pressure, and no episodes of hypotension or hypertension, in either group, or in the subset of 17 CRRT starts in vasopressor-dependent patients.ConclusionWe cannot recommend a slower pump speed start based on our findings, but advocate for close haemodynamic monitoring, as haemodynamic changes in individual patients cannot be predicted in advance.Copyright © 2011 S. Karger AG, Basel.

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