• Muscle & nerve · Dec 2011

    Comparative Study

    NMDA receptors at the endplate of rat skeletal muscles: precise postsynaptic localization.

    • Artem I Malomouzh, Leniz F Nurullin, Svetlana S Arkhipova, and Evgeny E Nikolsky.
    • Kazan Institute of Biochemistry and Biophysics, Russian Academy of Sciences, Kazan 420111, Russia. artur57@gmail.com
    • Muscle Nerve. 2011 Dec 1;44(6):987-9.

    AbstractIn this study we demonstrate expression of the N-methyl-D-aspartate receptor NR1 subunit in the rat neuromuscular junction of skeletal muscles of different functional types (extensor digitorum longus, soleus, and diaphragm muscles) using fluorescence immunocytochemistry. Electron microscopic immunocytochemistry has shown that the NR1 subunit is localized solely on the sarcolemma in the depths of the postsynaptic folds. These findings suggest participation of the glutamatergic signaling system in functioning of the adult mammalian neuromuscular junction.Copyright © 2011 Wiley Periodicals, Inc.

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