• Barnet Eskin, Richard D Shih, Frederick W Fiesseler, Brian W Walsh, John R Allegra, Michael E Silverman, Dennis G Cochrane, David F E Stuhlmiller, Oliver L Hung, Alex Troncoso, and Diane P Calello.
• Department of Emergency Medicine, Morristown Medical Center, Morristown, New Jersey.
• J Emerg Med. 2014 Jul 1;47(1):65-70.

BackgroundAlthough oral corticosteroids are commonly given to emergency department (ED) patients with musculoskeletal low back pain (LBP), there is little evidence of benefit.ObjectiveTo determine if a short course of oral corticosteroids benefits LBP ED patients.MethodsDesignRandomized, double-blind, placebo-controlled trial.SettingSuburban New Jersey ED with 80,000 annual visits.Participants18-55-year-olds with moderately severe musculoskeletal LBP from a bending or twisting injury ≤ 2 days prior to presentation. Exclusion criteria were suspected nonmusculoskeletal etiology, direct trauma, motor deficits, and local occupational medicine program visits.ProtocolAt ED discharge, patients were randomized to either 50 mg prednisone daily for 5 days or identical-appearing placebo. Patients were contacted after 5 days to assess pain on a 0-3 scale (none, mild, moderate, severe) as well as functional status.ResultsThe prednisone and placebo groups had similar demographics and initial and discharge ED pain scales. Of the 79 patients enrolled, 12 (15%) were lost to follow-up, leaving 32 and 35 patients in the prednisone and placebo arms, respectively. At follow-up, the two arms had similar pain on the 0-3 scale (absolute difference 0.2, 95% confidence interval [CI] -0.2, 0.6) and no statistically significant differences in resuming normal activities, returning to work, or days lost from work. More patients in the prednisone than in the placebo group sought additional medical treatment (40% vs. 18%, respectively, difference 22%, 95% CI 0, 43%).ConclusionWe detected no benefit from oral corticosteroids in our ED patients with musculoskeletal LBP.Copyright © 2014 Elsevier Inc. All rights reserved.

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