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Di Yi Jun Yi Da Xue Xue Bao · Mar 2002
Comparative Study[Alteration of Vitamin E levels in patients with pancreatic adenocarcinoma].
- De-Feng Wang, Xiao-Ci Qu, and Zheng-Qing Dai.
- Affiliated Hospital of Nantong Medical College, Nantong 226001, China.
- Di Yi Jun Yi Da Xue Xue Bao. 2002 Mar 1;22(3):210-1.
ObjectiveTo investigate the alterations of Vitamin E (Vit E) levels in patients with pancreatic adenocarcinoma and explore its mechanism of action.MethodA comparative analysis of the serum Vit E levels was conducted in patients with various pancreatic diseases.ResultsIn patients with acute pancreatitis, chronic pancreatitis and pancreatic adenocarcinoma, serum Vit E levels were significantly lower than those in normal subjects (P<0.05), and among the 3 groups of patients with pancreatic diseases, patients with the malignancies had significantly lower Vit E levels than the other 2 groups of patients (P<0.001).ConclusionSignificant reduction in Vit E levels occurs in patients with pancreatic adenocarcinoma, indicating that oxidation and anti-oxidation imbalance might be involved in the pathogenesis of the malignancy in the pancreas.
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