• Brain research · Feb 2004

    Effects of aging on hyperalgesia and spinal dynorphin expression in rats with peripheral inflammation.

    • Rui-Xin Zhang, Lixing Lao, Jian-Tian Qiao, and M A Ruda.
    • Center for Integrative, 3rd Floor, James Kernan Hospital Mansion, 2200 Kernan Drive, School of Medicine, University of Maryland, Baltimore, MD 21207, USA. Rzhan001@umaryland.edu
    • Brain Res. 2004 Feb 27;999(1):135-41.

    AbstractThe aging process is associated with various morphological and biochemical changes in the nervous system that may affect the processing of noxious inputs. This study showed greater hyperalgesia and up-regulation of spinal dynorphin (DYN) expression in aging than in young adult rats during CFA-induced peripheral inflammation. These data indicate that nociception is regulated differently in aging individuals, a fact that should be considered when selecting treatment strategies for aging populations with persistent pain.

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