• J. Clin. Invest. · May 2004

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    Sepsis: avoiding its deadly toll.

    • Thomas Decker.
    • Max F. Perutz Laboratories, University Departments at the Vienna Biocenter, Department of Microbiology and Genetics, University of Vienna, Vienna, Austria. thomas.decker@univie.ac.at
    • J. Clin. Invest. 2004 May 1;113(10):1387-9.

    AbstractSystemic bacterial infection may culminate in a frequently fatal septic shock syndrome. The underlying pathology is the result of an uncontrolled inflammatory response, stimulated by the pathogen and its products. Toll-like receptors (TLRs) are critically involved in sensing bacteria and, in the case of sepsis, stimulate a pathogenic response by the innate immune system. A new study reports a successful attempt to inhibit systemic inflammation in mice by disrupting the formation of complexes between Gram-positive bacteria and their cognate receptor, TLR2.

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