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- G Germann and H U Steinau.
- Abteilung für Verbrennungen, Plastische und Handchirurgie, Berufsgenossenschaftlichen Unfallklinik Ludwigshafen.
- Zentralbl Chir. 1993 Jan 1;118(5):290-302.
AbstractBurn treatment is a complex therapeutic regimen, enclosing immediate resuscitation, burn would care and the complete spectrum of surgical intensive care as well as plastic surgical reconstruction. The pathophysiology of a severe burn injury resembles a maximal trauma response by activating a wide variety of mediators, resulting in a generalized tissue edema (capillary leak). Most important are sufficient fluid resuscitation and primary care, correct referral to a burn center, early enteral feeding and a consequent operative tactic with early removal of necrotic tissue and stable wound coverage. Sepsis is still the major mortality factor (75%). Besides established methods like skin culturing, future efforts are directed towards the generation of composite skin grafts and an immunological approach to influence or prevent the course of a burn sepsis.
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