• J Neuroimmune Pharmacol · Jun 2013

    Case Reports

    Treatment of Complex Regional Pain Syndrome (CRPS) using low dose naltrexone (LDN).

    • Pradeep Chopra and Mark S Cooper.
    • Department of Medicine, Alpert Medical School of Brown University, 102 Smithfield Ave, Pawtucket, RI 02860, USA. painri@yahoo.com
    • J Neuroimmune Pharmacol. 2013 Jun 1;8(3):470-6.

    AbstractComplex Regional Pain Syndrome (CRPS) is a neuropathic pain syndrome, which involves glial activation and central sensitization in the central nervous system. Here, we describe positive outcomes of two CRPS patients, after they were treated with low-dose naltrexone (a glial attenuator), in combination with other CRPS therapies. Prominent CRPS symptoms remitted in these two patients, including dystonic spasms and fixed dystonia (respectively), following treatment with low-dose naltrexone (LDN). LDN, which is known to antagonize the Toll-like Receptor 4 pathway and attenuate activated microglia, was utilized in these patients after conventional CRPS pharmacotherapy failed to suppress their recalcitrant CRPS symptoms.

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