• Antimicrob. Agents Chemother. · Jul 2008

    Pharmacokinetics and tissue distribution of anidulafungin in rats.

    • Bharat Damle, Martin Stogniew, and James Dowell.
    • Pfizer Inc., New York, New York 10017, USA. bharat.damle@pfizer.com
    • Antimicrob. Agents Chemother. 2008 Jul 1;52(7):2673-6.

    AbstractThis study assessed the tissue distribution of anidulafungin in rats. Anidulafungin rapidly distributed into tissues, achieving peak concentrations within 30 min, and maintained levels above MICs for common pathogens over 72 h. In tissues susceptible to fungal infection (liver, lung, spleen, kidney), exposure was 9- to 12-fold higher than in plasma.

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