• Pediatr. Infect. Dis. J. · Apr 2016

    Application of a Prognostic Scale to Estimate the Mortality of Children Hospitalized with Community-Acquired Pneumonia.

    • Soraya Araya, Dolores Lovera, Claudia Zarate, Silvio Apodaca, Julia Acuña, Gabriela Sanabria, and Antonio Arbo.
    • From the *Department of Pediatrics, Institute of Tropical Medicine, Avda. Venezuela y Florida, Asunción, Paraguay; and †Facultad de Ciencias Médicas, Universidad Nacional de Asunción, Av. Mcal. Francisco Solano Lopez, San Lorenzo, Paraguay.
    • Pediatr. Infect. Dis. J. 2016 Apr 1; 35 (4): 369-73.

    BackgroundPneumonia is a major cause of mortality in children. The objective of this study was to construct a prognostic scale for estimation of mortality applicable to children with community-acquired pneumonia (CAP).MethodsThis observational study included patients younger than 15 years with a diagnosis of CAP who were hospitalized between 2004 and 2013. A point-based scoring system based on the modification of the PIRO scale used in adults with pneumonia was applied to each child hospitalized with CAP. It included the following variables: predisposition (age <6 months, comorbidity), insult [hypoxia (O2 saturation < 90), hypotension (according to age) and bacteremia], response (multilobar or complicated pneumonia) and organ dysfunction (kidney failure, liver failure and acute respiratory distress syndrome). One point was given for each feature that was present (range, 0-10 points). The association between the modified PIRO score and mortality was assessed by stratifying patients into 4 levels of risk: low (0-2 points), moderate (3-4 points), high (5-6 points) and very high risk (7-10 points).ResultsEight hundred sixty children hospitalized with CAP were eligible for study. The mean age was 2.8 ± 3.2 years. The observed mortality was 6.5% (56/860). Mortality ranged from 0% for a low PIRO score (0/708 pts), 18% (20/112 pts) for a moderate score, 83% (25/30 pts) for a high score and 100% (10/10 pts) for a very high modified PIRO score (P < 0.001).ConclusionThe present score accurately discriminated the probability of death in children hospitalized with CAP, and it could be a useful tool to select candidates for admission to intensive care unit and for adjunctive therapy in clinical trials.

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