• Giacomo Bellani, Andrea Coppadoro, Matteo Pozzi, Alfio Bronco, Daniela Albiero, Nilde Eronia, Valeria Meroni, Giacomo Grasselli, and Antonio Pesenti.
• Department of Health Science, University of Milan-Bicocca, Monza, Italy. Department of Emergency and Intensive Care, San Gerardo Hospital, Monza, Italy. giacomo.bellani1@unimib.it.
• Respir Care. 2016 Apr 1; 61 (4): 495-501.

BackgroundWe previously described an index, defined as the ratio between the inspiratory muscle pressure (Pmus) and the electrical activity of the diaphragm (EA(di)) (Pmus/EA(di) index). In the present work, we describe the trend of Pmus/EA(di) index over time, investigating whether it could be an indicator of muscular efficiency associated with risk factors for diaphragmatic injury and/or clinical outcomes.MethodsThis work is a retrospective analysis of subjects with measurements of Pmus/EA(di) index obtained, on different days, during assisted ventilation. Effects of Pmus/EA(di) index absolute value on clinical outcomes were investigated dividing subjects into those with Pmus/EA(di) index higher or lower than the median. Effects of Pmus/EA(di) index trend over time were analyzed, distinguishing between subjects with Pmus/EA(di) index increasing or decreasing.ResultsMean Pmus/EA(di) index was 1.04 ± 0.67, and the median (interquartile range) was 1.00 (0.59-1.34), without a systematic trend over the days. Demographic, ventilator, or outcome data did not significantly differ between subjects with Pmus/EA(di) index higher or lower than the median. Similarly, we did not find relevant differences in subjects with Pmus/EA(di) index increasing or decreasing over time.ConclusionsThe Pmus/EA(di) index value remained constant in each subject over time, although the inter-individual variability was high. Neither the Pmus/EA(di) index nor its trends appeared to be associated with ventilatory variables or clinical outcome.Copyright © 2016 by Daedalus Enterprises.

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