• T Akarsu, S Karaman, F Akercan, M Kazandi, M S Yucebilgin, and V Firat.
• Department of Anaesthesiology and Reanimation, Ege University Hospital, Izmir, Turkey.
• Clin Exp Obstet Gyn. 2004 Jan 1;31(2):133-6.

ObjectiveThis study was conducted to evaluate the analgesic efficacy of meloxicam in abdominal hysterectomy.MethodsThe study population consisted of 52 patients scheduled for total abdominal hysterectomy who were ASA 1 or 2 physical status female. Patients were allocated randomly to receive orally either 15 mg of meloxicam (Group M, n = 27) or placebo (Group P, n = 25) before anesthesia induction. After intravenous administration of 1.5 mg kg(-1) of tramadol, anesthesia was induced with an intravenous loading dose of 1-2 mg kg(-1) propofol. Anesthesia was maintained on intravenous infusion of propofol at 6-12 mg kg(-1) h plus tramadol at 1 mg kg(-1) h(-1), vecuronium, and a 2:1 nitrous oxide-oxygen mixture.ResultsThe relative propofol consumption was lower in Group M than in Group P, (p < 0.05). The time for analgesic rescue decreased in the order Group M > Group P (p < 0.01). The degree of sedation was similar between the groups (p > 0.05) and the visual analog scores (10-cm scale) and verbal rating scale data differences were present in the first 2 h only (p < 0.05). When side-effects were evaluated nausea and vomiting were found to be lower in group M than in group P (p < 0.05).ConclusionPreemptive meloxicam provided better postoperative analgesia than placebo.

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