• Coronary artery disease · May 2009

    Analysis of N-terminal pro-B-type natriuretic peptide in patients with acute coronary syndromes.

    • Giuseppe Coppola, Egle Corrado, Maria Cristina Mulè, Stefano Augugliaro, Angela Cucchiara, Giuseppina Novo, Gisella Amoroso, Pasquale Assennato, Enrico Hoffmann, Francesco Vitale, and Salvatore Novo.
    • Division of Cardiology, University Hospital P. Giaccone, University of Palermo, Palermo, Italy. g.coppola@unipa.it
    • Coron. Artery Dis. 2009 May 1; 20 (3): 225-9.

    BackgroundThe N-terminal portion of brain natriuretic peptide (NT-proBNP) has been identified as an indicator of prognosis in different cardiovascular diseases. The objective of this study was to determine the utility of measuring plasma NT-proBNP levels in patients with acute coronary syndromes.Methods And ResultsWe studied 66 patients admitted in our division for acute coronary syndromes. Patients underwent a venous blood sample within 24 h from the admission to determine NT-proBNP levels. Increasing plasma levels of NT-proBNP (in tertiles) was associated with a greater history of hypertension and current smoking, whereas biochemical parameters were associated with higher level of creatine kinase-MB mass, cardiac troponin I, and renal insufficiency. We detected correlations between the values of NT-proBNP and several variables; positive correlations were found between the values of NT-proBNP and creatinine (r=+0354; P=0.0024), cardiac troponin I levels (r=0320; P=0.0111), and creatine kinase-MB mass values (r=0261; P=0.035). An interesting result of our study was a significantly longer hospitalization in those patients belonging to the third tertile compared with those belonging to the first one (P=0.02). Finally, we showed a higher N-terminal brain natriuretic peptide level in patients with poor outcome during the hospitalization (left-ventricular systolic dysfunction, recurrent ischemic events, or death) compared with those who did not (3204+/-1841 vs. 836+/-1136, P=0.003).ConclusionMeasurement of B-type natriuretic peptide provides predictive information during the hospitalization in patients with acute coronary syndromes.

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