• Middle East J Anaesthesiol · Oct 2007

    Randomized Controlled Trial Comparative Study

    Analgesia for retrobulbar block--comparison of remifentanil, alfentanil and fentanyl.

    • Behzad Maghsoudi, Mohammad Rez Talebnejad, and Esfandyar Asadipour.
    • Department of Anesthesiology, Shiraz University of Medical Sciences, Shiraz, Iran. maghsodb@sums.ac.ir
    • Middle East J Anaesthesiol. 2007 Oct 1;19(3):595-602.

    BackgroundThe injection of retrobulbar block is associated with significant pain and discomfort. Therefore a short-acting IV analgesic before retrobulbar injection has been advocated.ObjectiveTo compare remifentanil, alfentanil and fentanyl in providing analgesia for retrobulbar block injection.Methods69 patients were enrolled randomly into three groups of 23 each to receive either Remifentanil 1 microg/kg, Alfentanil 20 microg/kg or Fentanyl 2 microg/kg as an IV bolus dose prior to retrobulbar injection. Mean arterial pressure (MAP) and heart rate (HR) were recorded and Numerical Pain Score (NPS) were assessed by a blinded observer.ResultsRemifentanil prevented increase in MAP and HR while alfentanil and fentanyl were ineffective in this purpose (p < 0.05). NPS was significantly lower in remifentanil group (p < 0.05).ConclusionRemifentanil 1 microg/kg prior to retrobulbar injection provide excellent hemodynamic stability and ensure analgesia.

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