• Mult. Scler. · Sep 2016

    Seronegative neuromyelitis optica spectrum disorder patients diagnosed using new diagnostic criteria.

    • Akiyuki Uzawa, Masahiro Mori, Tomohiko Uchida, Hiroki Masuda, Ryohei Ohtani, and Satoshi Kuwabara.
    • Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan auzawa@chiba-u.jp.
    • Mult. Scler. 2016 Sep 1; 22 (10): 1371-5.

    BackgroundRecently, new diagnostic criteria for neuromyelitis optica spectrum disorders (NMOSD) were published.ObjectiveOur primary aim was to evaluate the usefulness of the new diagnostic criteria in anti-aquaporin 4 (AQP4) antibody-negative cases.MethodsConsecutive 471 patients whose anti-AQP4 antibody was measured at Chiba University were reviewed.ResultsFour anti-AQP4 antibody negative-patients, who fulfilled the new diagnostic criteria for NMOSD but not 2006 diagnostic criteria for neuromyelitis optica (NMO), were identified. They showed high cerebrospinal fluid interleukin-6 and glial fibrillary acidic protein levels, an absence of oligoclonal bands and/or cloud-like enhancement on magnetic resonance imaging, which are compatible findings for NMO.ConclusionThe new diagnostic criteria are clinically useful in seronegative NMOSD.© The Author(s), 2015.

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