• Yasuki Fujita, Sayo Yamaguchi, Kayo Nakamura, Yuu Horiguchi, Daisuke Ikeda, Michiko Kaneko, Keiko Tomioka, Chiharu Tokunaga, and Takeo Iwakura.
• Department of Anesthesiology, Saiseikai Nakatsu Hospital, Osaka 530-0012.
• Masui. 2012 Jan 1;61(1):68-73.

BackgroundWe investigated whether the perioperative amino acid infusion with glucose is effective for preventing perioperative hypothermia and postoperative infection in patients undregoing total knee arthroplasty (TKA).MethodsForty patients undergoing TKA under general anesthesia were enrolled in this study. The patients were randomly allocated to two groups: AA group (n = 22), to which amino acid was infused, and AAGlu group (n = 18), to which amino acid and glucose were infused. The infusions were started before the anesthetic induction. Remifentanil was administered during the surgery, and the dose of remifentanil was adjusted to keep stable hemodynamics. The levels of blood glucose and body temperature were evaluated. We also recorded the frequency of additional use of nonsteroidal anti-inflammatory drugs, the days required until the wound closure, and complications in the post-operative period.ResultsThe levels of blood glucose in AAGlu group were significantly higher than those of AA group (P < 0.05). However, no significant differences were found in perioperative body temperature, postoperative days required until the wound closure and the frequency of additional use of analgesics between the groups.ConclusionsThese results suggest that in patients undergoing TKA receiveing amino acid infusion perioperatively, thermogenic effect and prevention of postoperative infection are similar whether exogenous glucose is infused or not.

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