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- W H Traub, I Schwarze, and D Bauer.
- Institut für Medizinische Mikrobiologie und Hygiene, Universität des Saarlandes, Homburg, Germany.
- Chemotherapy. 2000 Jan 1;46(1):1-14.
AbstractA multiple-antibiotic-resistant (MAR) strain of Klebsiella pneumoniae was introduced into a pediatric ward and subsequently colonized neonates of two wards with several cases of systemic infection. This strain produced an extended-spectrum beta-lactamase and was resistant to cefotaxime, ceftazidime, and, among others, all aminoglycosides including amikacin. The majority of representative isolates examined with macrorestriction analysis of genomic DNA (pulsed-field gel electrophoresis) were identical. The strain was susceptible to the innate antibacterial systems operative in fresh defibrinated blood from two adults. Combined human blood/antimicrobial drug assays documented the in vitro bactericidal activity of carbapenems (meropenem was slightly more effective than imipenem), fluoroquinolones (ciprofloxacin and trovafloxacin), and polymyxin B against this MAR strain of K. pneumoniae.Copyright 2000 S. Karger AG, Basel
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