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Anasthesiol Intensivmed Notfallmed Schmerzther · Aug 1996
Case Reports[Are monamine oxidase inhibitors in disposition to malignant hyperthermia contraindicated? Discussion based on a case report].
- F Wappler, A Köchling, and N Roewer.
- Abteilung für Anästhesiologie, Universitäts-Krankenhaus Eppendorf, Hamburg.
- Anasthesiol Intensivmed Notfallmed Schmerzther. 1996 Aug 1;31(6):349-53.
AbstractWe report on a young patient with a positive family history for malignant hyperthermia (MH), who was diagnosed as susceptible to MH in our malignant hyperthermia laboratory by the in vitro-contracture test. Prior to the investigation of MH-susceptibility, the patient had been on medication with moclobemide, a monoamine oxidase (MAO) inhibitor, over a period of 13 months for treatment of a hyperactivity disorder. During the therapy with moclobemide no signs of relevant side effects were observed. However, some authors regard MAO-inhibitors as MH-triggering agents. The risk of MH-patients due to the therapy with MAO-inhibitors and the association between MH and the neuroleptic malignant syndrome is discussed in this case report.
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