• Br J Clin Pract · Jun 1996

    Randomized Controlled Trial Comparative Study Clinical Trial

    Pain control after hysterectomy: an observer-blind, randomised trial of lornoxicam versus tramadol.

    • W Ilias and M Jansen.
    • Barmherzige Brüder Hospital, Vienna, Austria.
    • Br J Clin Pract. 1996 Jun 1;50(4):197-202.

    AbstractThis 24-hour, randomised, double-blind, placebo-controlled study compared the efficacy and tolerability of intravenous injections of lornoxicam 4 mg and 8 mg with tramadol 50 mg in 78 female patients aged 20-65 years with moderate to intolerable postoperative pain following mainly hysterectomy. Patients who received lornoxicam 8 mg had a significantly (p < 0.05) longer time to first remedication than placebo recipients and tended to have a greater reduction in pain intensity and a longer time to withdrawal due to "non-response' than tramadol and placebo patients. Lornoxicam was well tolerated at both doses and was associated with a lower incidence of adverse events than tramadol. Thus, intravenous lornoxicam at a dose of 8 mg is superior to placebo and at least as effective as intravenous tramadol 50 mg in relieving moderate to intolerable post-hysterectomy pain. Furthermore, lornoxicam seems to possess a more favourable tolerability profile than tramadol.

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