• Michael W Donnino, Lars W Andersen, Tyler Giberson, David F Gaieski, Benjamin S Abella, Mary Anne Peberdy, Jon C Rittenberger, Clifton W Callaway, Joseph Ornato, John Clore, Anne Grossestreuer, Justin Salciccioli, Michael N Cocchi, and National Post-Arrest Research Consortium.
• 1Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA. 2Department of Medicine, Division of Critical Care, Beth Israel Deaconess Medical Center, Boston, MA. 3Research Center for Emergency Medicine, Aarhus University, Aarhus, Denmark. 4Department of Emergency Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA. 5Department of Emergency Medicine, Virginia Commonwealth University Health System, Richmond, VA. 6Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, PA. 7Department of Anesthesia Critical Care, Division of Critical Care, Beth Israel Deaconess Medical Center, Boston, MA.
• Crit. Care Med. 2014 Aug 1; 42 (8): 1804-11.

ObjectiveRate of lactate change is associated with in-hospital mortality in post-cardiac arrest patients. This association has not been validated in a prospective multicenter study. The objective of the current study was to determine the association between percent lactate change and outcomes in post-cardiac arrest patients.DesignFour-center prospective observational study conducted from June 2011 to March 2012.SettingThe National Post-Arrest Research Consortium is a clinical research network conducting research in post-cardiac arrest care. The network consists of four urban tertiary care teaching hospitals.PatientsInclusion criteria consisted of adult out-of-hospital non-traumatic cardiac arrest patients who were comatose after return of spontaneous circulation.InterventionsNone.Measurements And Main ResultsThe primary outcome was survival to hospital discharge, and secondary outcome was good neurologic outcome. We compared the absolute lactate levels and the differences in the percent lactate change over 24 hours between survivors and nonsurvivors and between subjects with good and bad neurologic outcomes. One hundred patients were analyzed. The median age was 63 years (interquartile range, 50-75) and 40% were female. Ninety-seven percent received therapeutic hypothermia, and overall survival was 46%. Survivors and patients with good neurologic outcome had lower lactate levels at 0, 12, and 24 hours (p< 0.01). In adjusted models, percent lactate decrease at 12 hours was greater in survivors (odds ratio, 2.2; 95% CI, 1.1-6.2) and in those with good neurologic outcome (odds ratio, 2.2; 95% CI, 1.1-4.4).ConclusionLower lactate levels at 0, 12, and 24 hours and greater percent decrease in lactate over the first 12 hours post cardiac arrest are associated with survival and good neurologic outcome.

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