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- Shu-Chia Hsu, Wei-Tai Huang, Huei-Ming Yeh, and Allen Yi-Jer Hsieh.
- Department of Anesthesiology, Changhua Christian Hospital, Changhua City, Changhua County 500, Taiwan, ROC.
- J Chin Med Assoc. 2007 Nov 1;70(11):507-10.
AbstractMalignant hyperthermia is a rare anesthetic-related disorder. We present a case with unusual presentation. A boy aged 3 years and 9 months who was scheduled for Hotz's operation presented normally before the operation. Anesthesia was induced by atropine, thiopental and sevoflurane. Trachea intubation was facilitated by succinylcholine. Jaw stiffness was first noted although trachea was intubated without difficulty. The following tachycardia, hypercapnia and hyperthermia led to the diagnosis of malignant hyperthermia. Symptoms were relieved dramatically after the discontinuation of sevoflurane. Molecular genetic testing identified a novel ryanodine receptor (RYR1) mutation in exon 39, which confirmed malignant hyperthermia susceptibility in this patient.
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