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Am. J. Physiol. Gastrointest. Liver Physiol. · Nov 2015
ReviewMesenchymal stromal cell therapy in liver disease: opportunities and lessons to be learnt?
- Andrew Owen and Philip N Newsome.
- National Institute for Health Research Birmingham Liver Biomedical Research Unit and Centre for Liver Research, Birmingham, United Kingdom; and.
- Am. J. Physiol. Gastrointest. Liver Physiol. 2015 Nov 15;309(10):G791-800.
AbstractEnd-stage liver disease is responsible for 30,000 deaths per year in the United States alone, and it is continuing to increase every year. With liver transplantation the only curative treatment currently available, new therapies are in great demand. Mesenchymal stem cells (MSC) offer an opportunity to both treat liver inflammatory damage, as well as reverse some of the changes that occur following chronic liver injury. With the ability to regulate both the innate and adaptive immune system, as well as both inhibit and promote apoptosis of effector inflammatory cells, there are numerous therapeutic opportunities for MSC in acute and chronic liver disease. This article critically appraises the potential therapeutic roles of MSC in liver disease, as well as the barriers to their adoption into clinical practice.Copyright © 2015 the American Physiological Society.
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