• Cephalalgia · Jun 1992

    Beta-endorphin concentrations in the peripheral blood mononuclear cells of migraine and tension-type headache patients.

    • M Leone, P Sacerdote, D D'Amico, A E Panerai, and G Bussone.
    • Headache Center, Neurological Institute C. Besta, Milan, Italy.
    • Cephalalgia. 1992 Jun 1;12(3):154-7.

    AbstractLevels of beta-endorphin in peripheral blood mononuclear cells have been studied as a new approach to investigating opioid tone in migraine and tension-type headache. Sixty-one patients with migraine without aura, 39 with migraine with aura and 23 with episodic tension-type headache were compared with 37 healthy controls. Peripheral blood samples were taken from patients not enduring headache attacks and not undergoing prophylactic treatment. A significant reduction in peripheral blood mononuclear cell beta-endorphin concentrations was observed in migraine patients with and without aura, but not in tension-type headache patients. Altered transmitter modulation to peripheral blood mononuclear cells may be the cause of this alteration, which could be part of a more diffuse opioid system derangement in migraine subjects.

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