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Am J Hosp Palliat Care · May 2014
The role of analgesic adjustment strategies in achieving analgesic efficacy in opioid-tolerant hospice patients in China.
- Di Deng, Xin Wu, Ling Fu, Yunxiang Zhao, Gong Zhang, Chen Liang, Conghua Xie, and Yunfeng Zhou.
- 1Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Wuhan, China.
- Am J Hosp Palliat Care. 2014 May 1;31(3):315-21.
AbstractDiverse strategies of analgesic adjustment are often, respectively, used to sustain analgesic efficiency for opioid-tolerant patients with different refractory factors of pain. In order to select effective analgesic adjustment strategy for hospice patient without knowing explicit causes of diminishing analgesic efficiency, a retrospective data of 743 patients among 3760 hospice patients were analyzed. The efficacy and adverse effects were not significantly different among analgesic adjustment strategies at each adjustment. Opioid duration was not associated with clinical characteristics. For opioid-tolerant hospice patients, the analgesic adjustment strategy can be selected for individual patient. After repeated analgesic adjustments, opioid tapering may also occur.
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