• Microbes and infection · Dec 2009

    Review Historical Article

    Human tuberculosis--an ancient disease, as elucidated by ancient microbial biomolecules.

    • Helen D Donoghue.
    • Division of Infection and Immunity, Centre for Infectious Diseases and International Health, University College London, London W1T 4JF, UK. h.donoghue@ucl.ac.uk
    • Microbes Infect. 2009 Dec 1;11(14-15):1156-62.

    AbstractTuberculosis is a major cause of death but infected people with effective immunity may remain healthy for years, suggesting long-term co-existence of host and pathogen. Direct detection and characterisation of ancient microbial DNA and lipid biomarkers confirms palaeopathological diagnoses. Archaeological Mycobacterium tuberculosis resembles extant lineages indicating the timescale for evolutionary changes is considerably longer than originally believed.

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