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- J van der Grond, A F van Raamt, Y van der Graaf, W P T M Mali, and R H C Bisschops.
- Department of Radiology, E01.132, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands. j.vandergrond@azu.nl
- Neurology. 2004 Oct 26;63(8):1452-6.
ObjectiveTo investigate the relationship between morphologic differences in the circle of Willis and the presence and location of white matter lesions (WMLs).MethodsTwo hundred forty-three consecutive patients with clinical manifestations of atherosclerotic disease underwent MRI of the brain and MR angiography of the circle of Willis.ResultsSubjects with a fetal configuration of the circle of Willis demonstrated a decreased load of small (p < 0.01) and medium (p < 0.01) deep WMLs compared with subjects with a nonfetal configuration of the posterior part of the circle of Willis.ConclusionA fetal configuration of the posterior part of the circle of Willis may be an important protecting determinant in the etiology of white matter lesions.
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