• Alberto Zangrillo, Giuseppe Crescenzi, Giovanni Landoni, Albino Leoni, Giovanni Marino, Maria G Calabrò, Chiara Corno, Federico Pappalardo, and Ottavio Alfieri.
• Department of Cardiovascular Anesthesia, IRCCS San Raffaele Hospital, Milan, Italy.
• J. Cardiothorac. Vasc. Anesth. 2005 Apr 1; 19 (2): 193-6.

ObjectiveComplications occurring after coronary artery bypass graft (CABG) surgery, particularly neurologic damage, have been mainly correlated with the use of cardiopulmonary bypass (CPB). The aim of this work was to compare postoperative outcomes of patients undergoing CABG surgery, with or without the use of CPB, focusing on neurologic events.DesignObservational study.SettingUniversity tertiary care hospital.ParticipantsTwo thousand seven hundred and forty consecutive patients who underwent CABG surgery in the period January 1998 to January 2003.InterventionsNone.Measurements And Main ResultsFor 738 patients, the operation was performed off-pump (OP group), and for 2002 patients CPB was used (CPB group). OP and CPB groups were compared with regard to preoperative status, anesthetic management, and postoperative outcomes, by means of univariate and multivariate analyses. Surgeons' propensity to operate off-pump was based on patients' age, renal conditions, and hemodynamics. Univariate and multivariate analyses showed that CPB was associated with a higher incidence of type I neurologic events compared with OP technique (2.1% versus 0.9%, odds ratio [OR]: 2.6, 95% confidence interval [CI], 1.2-5.9). A history of previous stroke (OR: 2.7, 95% CI, 1.2-5.9) and advanced age (OR: 1.06 per year, 95% CI, 1.02-1.09) were additional independent predictors of postoperative type I neurologic events.ConclusionsIn the authors' experience, off-pump CABG surgery offers some benefits compared with CPB in respect to major neurologic complications.

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