• Konrad Schwarzkopf, Torsten Schreiber, Niels-Peter Preussler, Elke Gaser, Lars Hüter, Reinhard Bauer, Harald Schubert, and Waheedullah Karzai.
• Department of Anesthesiology and Intensive Care Medicine, University of Jena, Germany.
• J. Cardiothorac. Vasc. Anesth. 2003 Feb 1;17(1):73-5.

ObjectiveTo study how desflurane, isoflurane, and propofol affect pulmonary perfusion, shunt fraction, and systemic oxygenation during one-lung ventilation (OLV) in vivo.DesignProspective animal study with a crossover design.SettingAnimal laboratory of a university hospital.ParticipantsTwelve female pigs.InterventionsThe pigs were anesthetized, tracheally intubated, and mechanically ventilated. After placement of femoral arterial and thermodilution pulmonary artery catheters, a left-sided, double-lumen tube (DLT) was placed via tracheotomy. After DLT placement, F(I)O(2) was adjusted at 0.8, and anesthesia was continued in random order with 1 minimal alveolar concentration of desflurane, 1 minimal alveolar concentration of isoflurane, or propofol.Measurements And Main ResultsMeasurements of respiratory and hemodynamic parameters were made after stabilization at each anesthetic. During OLV, perfusion of the nonventilated lung and shunt fraction were comparable during all 3 anesthetics. PaO(2) was lower during desflurane and isoflurane anesthesia as compared with propofol anesthesia. Mixed venous PO(2) and cardiac output were lower with desflurane and isoflurane as compared with propofol.ConclusionsIn a clinically relevant model of OLV cardiac output, PaO(2) and mixed venous PO(2) decreased during desflurane and isoflurane as compared with propofol, whereas perfusion of the nonventilated lung and shunt fraction remained comparable.Copyright 2003, Elsevier Science (USA). All rights reserved.

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