• Jared G Clay, J Kevin Grayson, and Dustin Zierold.
• David Grant Medical Center 60MSGS/SGCQ 101 Bodin Circle, Travis AFB, CA 94535, USA.
• Mil Med. 2010 Apr 1;175(4):280-4.

ObjectiveTo compare advanced hemostatic dressings: HemCon (HC), QuikClot ACS+ (advanced clotting sponge, and two granular agents: Celox (CX) and WoundStat (WS), with a standard field dressing in a swine model of extremity hemorrhage.MethodsWe randomized 30 animals to treatment with a standard dressing or a hemostatic agent applied to a 2 x 6-mm injury in the femoral artery and vein after 45 s of free bleeding. Animals received 500 mL Hextend 15 min after the bleeding commenced without further resuscitation. End point was survival to 120 min or non-survivable blood pressure.ResultsSurvival to 120 min among treatment groups was 100% (WS), 83% (CX), 67% (HC), and 50% (ACS+). No control animals survived. Postinjury blood loss (mL/kg) was 4.6 (WS), 12.9 (CX), 10.0 (HC), and 15.8 (ACS+) compared to 27.0 for controls.ConclusionAll hemostatic dressings result in significantly less blood loss and improved survival over standard gauze dressing.

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