• J. Pediatr. Surg. · Mar 2011

    Case Reports

    Resolution of opioid-induced postoperative ileus in a newborn infant after methylnaltrexone.

    • Lars Garten, Petra Degenhardt, and Christoph Bührer.
    • Department of Neonatology, Charité University Medical Center, Berlin, Germany. lars.garten@charite.de
    • J. Pediatr. Surg. 2011 Mar 1;46(3):e13-5.

    AbstractTransient impairment of bowel function is a frequent and distressing problem in neonates on opioid-induced analgesia. Methylnaltrexone, a peripheral-acting μ-opioid receptor antagonist, has been studied in adults for the treatment of opioid-induced constipation in advanced illness and has been suggested as a promising therapeutic concept for reducing postoperative ileus. Here, we report on a newborn infant on fentanyl analgesia after major abdominal surgery with aggravated ileus. After 8 days of quiescent bowel, the patient's intestinal dysmotility resolved within 15 minutes after intravenous administration of methylnaltrexone (0.15 mg/kg body weight). Methylnatrexone was repeated daily until cessation of fentanyl administration. There were no signs of pain or opioid withdrawal.Copyright © 2011 Elsevier Inc. All rights reserved.

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