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Clin Toxicol (Phila) · Jun 2007
Case ReportsReversal of salicylate-induced euglycemic delirium with dextrose.
- Nick Kuzak, Jeff R Brubacher, and James R Kennedy.
- Department of Emergency Medicine and Anesthesia, University of British Columbia, Vancouver, British Columbia, Canada. nickkuzak@hotmail.com
- Clin Toxicol (Phila). 2007 Jun 1;45(5):526-9.
AbstractSalicylate poisoning inhibits Krebs cycle enzymes and uncouples oxidative phosphorylation. Under these circumstances, we hypothesize that CNS glucose supply is sometimes unable to keep up with demand resulting in hypoglycorrhacia and delirium even in the face of serum euglycemia. Supporting this conjecture, we report two euglycemic patients with salicylate-induced delirium who responded to boluses of concentrated dextrose with a prompt improvement in mental status.
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