• Bhishamjit S Chera, Avraham Eisbruch, Barbara A Murphy, John A Ridge, Patrick Gavin, Bryce B Reeve, Deborah Watkins Bruner, and Benjamin Movsas.
• Affiliations of authors: Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC (BSC, BBR); Department of Radiation Oncology, University of Michigan, Ann Arbor, MI (AE); Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN (BAM); Fox Chase Cancer Center, Philadelphia, PA (JAR); Grand Rapids Clinical Oncology Program, Grand Rapids, MI (PG); Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA (DWB); Henry Ford Hospital, Detroit, MI (BM). bchera@med.unc.edu.
• J. Natl. Cancer Inst. 2014 Jul 1;106(7).

AbstractWe identified a standard core set of patient-reported symptoms and health-related quality-of-life (HRQOL) domains to be assessed in head and neck (H&N) cancer clinical trials. The core symptom and HRQOL domain scores were used to guide recommendations by a working group of experts as part of a National Cancer Institute Symptom Management and HRQOL Clinical Trials Planning Meeting. A PubMed search was conducted using the search terms of "health-related quality of life" and "head & neck cancer," limited to publications from January 1, 2000, to December 31, 2010. Fifty-four articles were used to guide the choice of recommendations. Twenty-nine symptoms and nine domains were identified, from which 12 H&N-specific core symptoms and HRQOL domains were recommended: swallowing, oral pain, skin changes, dry mouth, dental health, opening mouth/trismus, taste, excess/thick mucous/saliva, shoulder disability/motion, voice/hoarseness, social domain, and functional domain. This core set of 12 H&N-specific, patient-reported symptoms and HRQOL domains should be assessed in future H&N cancer clinical trials.© The Author 2014. Published by Oxford University Press. All rights reserved.

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