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Curr Opin Crit Care · Feb 2006
ReviewDesigning clinical trials in acute lung injury/acute respiratory distress syndrome.
- David T Huang and Derek C Angus.
- The Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, PA 15261, USA. huangdt@ccm.upmc.edu
- Curr Opin Crit Care. 2006 Feb 1; 12 (1): 32-6.
Purpose Of ReviewTo review the implications of recent literature for clinical trial design in acute lung injury/acute respiratory distress syndrome (ARDS).Recent FindingsRefinement of acute lung injury/acute respiratory distress syndrome diagnostic criteria and study enrollment criteria, greater efforts to define usual care appropriately, and balancing of efficacy and effectiveness design principles will be key components of future trials.SummaryClinical trial design in acute lung injury/acute respiratory distress syndrome faces many challenges. Although we have learned much from past trials, persistent design dilemmas must be addressed for future trials.
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