• Michael A Downes, Leonie A Calver, and Geoffrey K Isbister.
• Department of Emergency Medicine, Calvary Mater Newcastle, Newcastle, New South Wales, Australia; Faculty of Public Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia; Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Newcastle, New South Wales, Australia.
• Emerg Med Australas. 2014 Jun 1;26(3):286-90.

ObjectiveTo assess the effect of intralipid emulsion therapy (ILE) in sedating drugs presenting to an urban emergency department.MethodsFollowing the introduction of a clinical protocol for the use of ILE a retrospective chart review was undertaken, which describes the use of ILE in treating sedating drug overdose in a facility with a tertiary referral level clinical toxicology unit. Demographic data as well as details of drug ingested, physiological parameters and disposition were extracted from the medical record.ResultsOver a 7 month period nine cases were treated with intralipid, of which two were male and the median age was 33 years (17-52 years). Endotracheal intubation was required in seven cases and of the other two, one required a nasopharyngeal airway for several hours while being observed in a critical care area. One patient was managed in the intensive care unit without intubation. The median duration of ventilation in the seven patients was 31 h (22-82 h), and median length of stay for all nine cases was 63 h (24-133 h).ConclusionThis study does not support any clinically significant effect of intralipid in sedating drug overdose.© 2014 Australasian College for Emergency Medicine and Australasian Society for Emergency Medicine.

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