• I Frerichs, G Hahn, T Schröder, and G Hellige.
• Department of Anaesthesiological Research, Centre of Anaesthesiology, Emergency and Intensive Care Medicine, University of Göttingen, Germany.
• Intensive Care Med. 1998 Aug 1; 24 (8): 829836829-36.

ObjectiveTo apply electrical impedance tomography (EIT) and the new evaluation approach (the functional EIT) in monitoring the development of artificial lung injury.DesignAcute experimental trial.SettingOperating room for animal experimental studies at a university hospital.SubjectsFive pigs (41.3 +/- 4.1 kg, mean body weight +/- SD).InterventionsThe animals were anaesthetised and mechanically ventilated. Sixteen electrodes were attached on the thoracic circumference and used for electrical current injection and surface voltage measurement. Oleic acid was applied sequentially (total dose 0.05 ml/kg body weight) into the left pulmonary artery to produce selective unilateral lung injury.Measurements And ResultsThe presence of lung injury was documented by significant changes of PaCO2 (40.1 mmHg vs control 37.1 mmHg), PaO2 (112.3 mmHg vs 187.5 mmHg), pH (7.35 vs 7.42), mean pulmonary arterial pressure (29.2 mmHg vs 20.8 mmHg) and chest radiography. EIT detected 1) a regional decrease in mean impedance variation over the affected left lung (-41.4% vs control) and an increase over the intact right lung (+ 20.4% vs control) indicating reduced ventilation of the affected, and a compensatory augmented ventilation of the unaffected lung and 2) a pronounced fall in local baseline electrical impedance over the injured lung (-20.6% vs control) with a moderate fall over the intact lung (-10.0% vs control) indicating the development of lung oedema in the injured lung with a probable atelectasis formation in the contralateral one.ConclusionThe development of the local impairment of pulmonary ventilation and the formation of lung oedema could be followed by EIT in an experimental model of lung injury. This technique may become a useful tool for monitoring local pulmonary ventilation in intensive care patients suffering from pulmonary disorders associated with regionally reduced ventilation, fluid accumulation and/or cell membrane changes.

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