• Laurence M Katz, James E Manning, Shane McCurdy, L Bruce Pearce, Maria S Gawryl, Yuanfan Wang, Chad Brown, and Carolina Resuscitation Research Group.
• Department of Emergency Medicine, School of Medicine, University of North Carolina, Neurosciences Hospital Ground Floor, 101 Manning Drive, CB 7594, Chapel Hill, NC 27599, USA. lkatz@med.unc.edu
• Resuscitation. 2002 Jul 1; 54 (1): 77-87.

BackgroundBlunt abdominal trauma that leads to hemorrhagic shock and cardiac arrest is almost always fatal in the prehospital setting. The current study investigated whether a hemoglobin-based oxygen carrier (HBOC-201) could maintain organ viability during an exsanguinating liver injury and allow for prolonged survival. This hypothesis was tested in a large animal model that simulated blunt abdominal trauma with major organ injury.MethodsSwine underwent a liver crush, laceration and 50 ml/kg initial blood loss. The liver bled at 3 ml/kg per min during the resuscitation phase. No fluid (NF=6), hetastarch (HES=8), or HBOC-201 (HBOC=8) was given during the resuscitation phase. Swine alive 60 min after the initial injury underwent liver repair and 96 h observation.ResultsAll HBOC swine survived 60 min versus none of the NF or HES swine (P<0.05). All HBOC swine survived 24 h and 7/8 survived 96 h with good functional recovery.ConclusionsHBOC resuscitation during liver bleeding in a swine model of hemorrhagic shock and liver injury allowed for 96 h survival. No fluid or HES in the same model was fatal.

22 keywords...

hide…