• Br Med J (Clin Res Ed) · May 1987

    Randomized Controlled Trial Clinical Trial

    Successful treatment of acute mountain sickness with dexamethasone.

    • G Ferrazzini, M Maggiorini, S Kriemler, P Bärtsch, and O Oelz.
    • Br Med J (Clin Res Ed). 1987 May 30;294(6584):1380-2.

    AbstractA double blind, randomised, placebo controlled trial of treatment with dexamethasone for acute mountain sickness was performed in the Capanna "Regina Margherita" at an altitude of 4559 m in the Alps Valais. After 12-16 hours of treatment (8 mg dexamethasone initially, followed by 4 mg every six hours) the mean acute mountain sickness score decreased significantly from 5.4 to 1.3, and eight of 17 patients became totally asymptomatic. Mean arterial oxygen saturation rose from 75.5% to 82.0%, and there was a small increase in standard spirometric measurements. In the placebo group none of these variables changed significantly. It is concluded that dexamethasone may be used as emergency treatment for acute mountain sickness to facilitate safe descent to a lower altitude.

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