• J. Pharm. Pharmacol. · Jun 1994

    Evaluation of free radical production in an ischaemia-reperfusion model in the rabbit using a tourniquet.

    • J Chopineau, M F Sommier, and V Sautou.
    • Laboratoire de Pharmacie Clinique et Biotechnique, Faculté de Pharmacie, Clermont-Ferrand, France.
    • J. Pharm. Pharmacol. 1994 Jun 1;46(6):519-20.

    AbstractUse of a tourniquet on a limb to stem blood flow is frequent in surgery. However, this results in an ischaemia-reperfusion effect that causes damage through the production of free radicals. The aim of this work was to evaluate this production of free radicals in an ischaemia-reperfusion model in the rabbit after placement of a tourniquet. Plasma lipoperoxides were measured by high-performance liquid chromatography using the malondialdehyde assay method. We found significant (P < 0.01) production of free radicals 1 min after release of the tourniquet compared with controls; no variation in levels of free radicals was observed during the ischaemia phase.

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